Influence of hydrophilic polymers on celecoxib complexation with hydroxypropyl β-cyclodextrin
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چکیده
منابع مشابه
Influence of hydrophilic additives on the supersaturation and bioavailability of dutasteride-loaded hydroxypropyl-β-cyclodextrin nanostructures
The objectives of this study were to develop a novel solid dutasteride formulation with improved physicochemical properties and oral bioavailability, and to examine the correlation between its in vitro dissolution and in vivo pharmacokinetic parameters. Hydroxypropyl-β-cyclodextrin (HP-β-CD) nanostructures with or without hydrophilic additives were manufactured using the supercritical antisolve...
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To improve the stability and oral bioavailability of Z-ligustilide (LIG), the inclusion complex of LIG with hydroxypropyl- β-cyclodextrin (HP-β-CD) was prepared by the kneading method and characterized by UV-Vis spectroscopy, differential thermal analysis (DTA) and Fourier transform infrared (FTIR) spectroscopy. LIG is capable of forming an inclusion complex with HP-b-CD and the stoichiometry o...
متن کاملComplexation of Amlodipine Besylate with β-Cyclodextrin.
In this paper the procedure for the preparation of inclusion compounds of bioactive substance 2-[(2-aminoetoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridine dicarboxylic acid 3-ethyl-5-methyl esterbenzene sulfonate, called amlodipine besylate with β-cyclodextrin (β-CD) and their structural characterization was described. Molecular inclusion compound of amlodipine besylate is obt...
متن کاملEffect of Polyvinylpyrrolidone on Complexation and Dissolution Rate of ß- and Hydroxypropyl-ß- Cyclodextrin Complexes of Celecoxib
Complexation of celecoxib with ß-cyclodextrin and hydroxypropyl-ß-cyclodextrin in the presence and absence of polyvinylpyrrolidone and the effect of polyvinylpyrrolidone on the solubilizing efficiency of cyclodextrins and on the dissolution rate of celecoxib from the cyclodextrin complexes were investigated. The phase solubility studies indicated the formation of celecoxib-ß-cyclodextrin and ce...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2006
ISSN: 1530-9932
DOI: 10.1208/pt070379